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KMID : 1161420110140040441
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Journal of Medicinal Food
2011 Volume.14 No. 4 p.441 ~ p.443
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Modulation of Leptin Levels by Oxidized Linoleic Acid: A Connection to Atherosclerosis?
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Penumetcha Meera
Merchant Nadya
Parthasarathy Sampath
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Abstract
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The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r?/?) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052?±?601?pg/mL vs. 10,950?±?541?pg/mL; P?
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KEYWORD
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dietary oxidized fat, food efficiency, obesity
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